Type 2 Diabetes Epidemic

According to the latest diabetes statistics from the Centers for Disease Control and Prevention, nearly 24 million people in the U.S. have diabetes, of which almost 6 million don’t know they are diabetic. In addition, at least 57 million Americans have prediabetes, a state with an increased risk of developing Type 2 diabetes. In 2007 alone, 1.6 million adults were newly diagnosed with Type 2 diabetes. The implications of the diabetes epidemic go far beyond the disease itself because diabetes affects the occurrence of other serious conditions, including cardiovascular disease, the leading cause of death in industrialized societies.

Inflammation Contributes to Type 2 Diabetes

Type 2 diabetes involves inadequate insulin secretion and resistance to the action of insulin. Recent data indicates that inflammation is an important factor in the development of both insulin resistance and Type 2 diabetes. The importance of inflammation is demonstrated in part by the fact that production of inflammatory mediators is increased under conditions of obesity and insulin resistance. The actions of these inflammatory mediators promote pancreatic beta-cell dysfunction and render peripheral tissues resistant to insulin through mechanisms that remain unclear.

Inflammation Is the Key to Obesity-diabetes Link

Obesity is one of the biggest risk factors for Type 2 diabetes. However, the presence of inflammation is key. Recent studies suggest that obesity without inflammation does not result in insulin resistance or Type 2 diabetes.

When a person becomes obese, they develop steatosis (increased fat in the liver), which leads to macrophage infiltration into the liver. Obesity also leads to macrophage accumulation in fat tissue. Macrophages are key players in the immune and inflammatory responses.

When these cells get into fat or liver tissue, they release cytokines, which are chemical messenger molecules used by immune and nerve cells to communicate. These cytokines cause the neighboring liver, muscle or fat cells to become insulin resistant, which in turn leads to Type 2 diabetes.

Inflammation Promotes Diabetic Complications

It is well known that diabetic complications are responsible for the vast majority of diabetes-related deaths and inflammation has been linked with all diabetic complications.

Cardiovascular disease: Inflammation results in vascular damage leading to atherosclerotic plaque formation and increased risk for myocardial infarction and stroke.

Renal insufficiency or end-stage renal disease: Infiltration of inflammatory cells into the renal microvasculature causes the development of diabetic nephropathy.

Retinopathy: Inflammation causes retinal vasculature damage and leads to blood vessel breakdown and macular edema, the main cause of vision loss in diabetes. Clinical studies also show that increased inflammation is associated with the more severe forms of diabetic retinopathy.

Control of Inflammation May Reduce the Risk of Diabetes

Current recommendations to prevent Type 2 diabetes center on lifestyle modifications, such as diet and exercise. Clinical trials have established the efficacy of lifestyle intervention, as well as pharmacologic interventions that target glycemic control and treatment of other cardiovascular risk factors, such as hypertension, hyperlipidemia, and obesity. However, diabetes still developed in a substantial percentage of individuals who received intensive intervention in these trials.

Because inflammation promotes insulin resistance and Type 2 diabetes, balancing inflammatory response may therefore offer a novel approach to the prevention and treatment of diabetes.

FlameEz Remedies Relieve Inflammation in Diabetes

Nutrients, herbs, and herbal remedies have been used to reduce glucose levels in diabetes. FlameEz-Glucose, however, is the only natural remedy formulated to relieve chronic inflammation in diabetes. The active ingredients of FlameEz-Glucose work synergistically to balance the immune response and relieve systemic inflammation. The formula works as a powerful total body cleanser to remove toxic substances, i.e., inflammatory cells and their metabolites and debris.



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